DISEASES

Disease-gene associations mined from literature

Literature associating PACRG and leprosy

PACRG [ENSP00000337946]

Molecular chaperone/chaperonin-binding protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease; Armadillo-like helical domain containing

Synonyms:  PACRG,  Q96M98,  GLUP,  Q96M98p,  hQ96M98 ...

Linkouts:  STRING  Pharos  UniProt  OMIM