DISEASES

Disease-gene associations mined from literature

Literature associating SRA1 and X-linked cone-rod dystrophy 2

SRA1 [ENSP00000337513]

Steroid receptor RNA activator protein; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis; Belongs to the SRA1 family.

Synonyms:  SRA1,  SRA1p,  hSRA1,  Q9HD15,  PP7684 ...

Linkouts:  STRING  Pharos  UniProt  OMIM