DISEASES

Disease-gene associations mined from literature

Literature associating CMTR2 and vestibulocochlear nerve disease

CMTR2 [ENSP00000337512]

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs; Seven-beta-strand methyltransferase motif containing

Synonyms:  CMTR2,  CMTR2p,  hCMTR2,  H3BNZ8,  H3BR19 ...

Linkouts:  STRING  Pharos  UniProt