DISEASES

Disease-gene associations mined from literature

Literature associating AZIN1 and corpus luteum cyst

AZIN1 [ENSP00000337180]

Ornithine decarboxylase antizyme inhibitor; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding. Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.

Synonyms:  AZIN1,  AZIN1p,  hAZIN1,  A0A024R9C7,  E5RIB7 ...

Linkouts:  STRING  Pharos  UniProt