Literature associating RLTPR and immunodeficiency 16
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing.
Synonyms: RLTPR, CARMIL2, Q6F5E8, R4GNC4, CARMIL2p ...