DISEASES

Disease-gene associations mined from literature

Literature associating COQ6 and end stage renal failure

COQ6 [ENSP00000333946]

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3- polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Synonyms:  COQ6,  COQ6p,  hCOQ6,  G3V2L5,  G3V3A1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM