Disease-gene associations mined from literature

Literature associating MRGPRX2 and Stevens-Johnson syndrome

MRGPRX2 [ENSP00000333800]

Mas-related G-protein coupled receptor member X2; Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo- allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A; G protein-coupled receptors, Class A orphans

Synonyms:  MRGPRX2,  MRGPRX2p,  hMRGPRX2,  MGRG3,  Q96LB1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM