DISEASES

Disease-gene associations mined from literature

Literature associating RAB11B and rectum adenocarcinoma

RAB11B [ENSP00000333547]

RAB11B, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis; RAB, member RAS oncogene GTPases

Synonyms:  RAB11B,  RAB11Bp,  hRAB11B,  B4DMK0,  M0R2D0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM