DISEASES

Disease-gene associations mined from literature

Literature associating FOXL2 and ovarian sex-cord stromal tumor

FOXL2 [ENSP00000333188]

Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2; Forkhead boxes

Synonyms:  FOXL2,  FOXL2p,  hFOXL2,  P58012,  Q4JHB5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM