Literature associating PLA2G6 and hereditary spastic paraplegia 35
Intracellular membrane-associated calcium-independent phospholipase A2 beta; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods; Ankyrin repeat domain containing
Synonyms: PLA2G6, PLA2G6p, hPLA2G6, B0QYE9, E7EX67 ...