Literature associating PARPBP and autosomal recessive hypercholesterolemia
PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family.
Synonyms: PARPBP, A0A024RBG0, B4DT40, B4DZ31, C12ORF48 ...