DISEASES

Disease-gene associations mined from literature

Literature associating CCR4 and T-cell lymphoblastic leukemia/lymphoma

CCR4 [ENSP00000332659]

Chemokine (C-C motif) receptor 4; High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Synonyms:  CCR4,  CCR4p,  hCCR4,  A0N0Q1,  P51679 ...

Linkouts:  STRING  Pharos  UniProt  OMIM