Literature associating CCR4 and T-cell lymphoblastic leukemia/lymphoma
Chemokine (C-C motif) receptor 4; High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Synonyms: CCR4, CCR4p, hCCR4, A0N0Q1, P51679 ...