DISEASES

Disease-gene associations mined from literature

Literature associating RNLS and chronic kidney disease

RNLS [ENSP00000332530]

Renalase, FAD-dependent amine oxidase; Catalyzes the oxidation of the less abundant 1,2- dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta- NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Synonyms:  RNLS,  G9G137,  G9G138,  Q5VYX0,  C10orf59 ...

Linkouts:  STRING  Pharos  UniProt  OMIM