Literature associating HIST2H2AC and amyotrophic lateral sclerosis type 6
Histone cluster 2, H2ac; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms: HIST2H2AC, Q16777, H2AFQ, Q16777p, hQ16777 ...