Literature associating GDF3 and germ cell and embryonal cancer
Growth differentiation factor 3; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto; Belongs to the TGF-beta family.
Synonyms: GDF3, GDF3p, hGDF3, Q9NR23, Q9NR23p ...