DISEASES

Disease-gene associations mined from literature

Literature associating IRX3 and transient refractive change

IRX3 [ENSP00000331608]

Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes

Synonyms:  IRX3,  IRX3p,  hIRX3,  J3QR11,  P78415 ...

Linkouts:  STRING  Pharos  UniProt  OMIM