DISEASES

Disease-gene associations mined from literature

Literature associating FES and Miller-Dieker lissencephaly syndrome

FES [ENSP00000331504]

Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28; F-BAR domain containing

Synonyms:  FES,  A0A024RC92,  C9J3W6,  E7EMJ7,  E7ENM8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM