DISEASES

Disease-gene associations mined from literature

Literature associating P2RX7 and bone cancer

P2RX7 [ENSP00000330696]

Purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells; Purinergic receptors P2X

Synonyms:  P2RX7,  P2RX7p,  hP2RX7,  B3KR29,  F5H237 ...

Linkouts:  STRING  Pharos  UniProt