DISEASES

Disease-gene associations mined from literature

Literature associating IFNL1 and psoriasis 12

IFNL1 [ENSP00000329991]

Interferon, lambda 1; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression; Interferons

Synonyms:  IFNL1,  IFNL1p,  hIFNL1,  E2JF13,  Q8IU54 ...

Linkouts:  STRING  Pharos  UniProt