DISEASES

Disease-gene associations mined from literature

Literature associating PSMG1 and Down syndrome

PSMG1 [ENSP00000329915]

Proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Synonyms:  PSMG1,  PSMG1p,  hPSMG1,  F8WBH7,  O95456 ...

Linkouts:  STRING  Pharos  UniProt  OMIM