DISEASES

Disease-gene associations mined from literature

Literature associating SOCS1 and essential thrombocythemia

SOCS1 [ENSP00000329418]

Suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway; SH2 domain containing

Synonyms:  SOCS1,  SOCS1p,  hSOCS1,  O15524,  Q4JHT5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM