DISEASES

Disease-gene associations mined from literature

Literature associating SLX1B and karyomegalic interstitial nephritis

SLX1B [ENSP00000328940]

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.

Synonyms:  SLX1B,  SLX1Bp,  hSLX1B,  H3BRR6,  GIYD1 ...

Linkouts:  STRING  Pharos