Disease-gene associations mined from literature

Literature associating GLRX5 and sideroblastic anemia

GLRX5 [ENSP00000328570]

Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).

Synonyms:  GLRX5,  GLRX5p,  hGLRX5,  Q86SX6,  C14orf87 ...

Linkouts:  STRING  Pharos  UniProt  OMIM