Disease-gene associations mined from literature

Literature associating DENND5A and lissencephaly 8

DENND5A [ENSP00000328524]

DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family.

Synonyms:  DENND5A,  DENND5Ap,  hDENND5A,  B3KWN5,  B4DFB6 ...

Linkouts:  STRING  Pharos  UniProt