Disease-gene associations mined from literature

Literature associating MINA and squamous cell carcinoma

MINA [ENSP00000328251]

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.

Synonyms:  D6RCB6,  H0Y8K4,  H0Y9L8,  Q8IUF8,  RIOX2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM