DISEASES

Disease-gene associations mined from literature

Literature associating RLIM and syndromic X-linked intellectual disability

RLIM [ENSP00000328059]

Ring finger protein, LIM domain interacting; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals; Ring finger proteins

Synonyms:  RLIM,  Q9NVW2,  Q9NVW2p,  hQ9NVW2,  RNF12 ...

Linkouts:  STRING  Pharos  UniProt