Literature associating PRR7 and autosomal dominant Robinow syndrome 3
Synaptic proline-rich membrane protein; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.
Synonyms: PRR7, PRR7p, hPRR7, A0A024R7R8, D6RFJ4 ...