DISEASES

Disease-gene associations mined from literature

Literature associating SRRM1 and dendritic cell thymoma

SRRM1 [ENSP00000326261]

SR-related nuclear matrix protein of 160 kDa; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Synonyms:  SRRM1,  SRRM1p,  hSRRM1,  A9Z1X7,  M0QXG5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM