DISEASES

Disease-gene associations mined from literature

Literature associating PLAG1 and adenoma

PLAG1 [ENSP00000325546]

Pleiomorphic adenoma gene 1 protein; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia; Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  PLAG1,  PLAG1p,  hPLAG1,  A0A024R7Z0,  A7IT79 ...

Linkouts:  STRING  Pharos  UniProt  OMIM