Literature associating PLAG1 and myxoid leiomyosarcoma
Pleiomorphic adenoma gene 1 protein; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia; Belongs to the krueppel C2H2-type zinc-finger protein family.
Synonyms: PLAG1, PLAG1p, hPLAG1, A0A024R7Z0, A7IT79 ...