DISEASES

Disease-gene associations mined from literature

Literature associating CD28 and diffuse infiltrative lymphocytosis syndrome

CD28 [ENSP00000324890]

T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.

Synonyms:  CD28,  CD28p,  hCD28,  P10747,  P10747p ...

Linkouts:  STRING  Pharos  UniProt  OMIM