DISEASES

Disease-gene associations mined from literature

Literature associating PPP2R1A and hereditary Wilms' tumor

PPP2R1A [ENSP00000324804]

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.

Synonyms:  PPP2R1A,  PPP2R1Ap,  hPPP2R1A,  A8K7B7,  B3KQV6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM