Disease-gene associations mined from literature

Literature associating TCHP and petrous apex meningioma

TCHP [ENSP00000324404]

Mitochondrial protein with oncostatic activity; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis; Belongs to the TCHP family.

Synonyms:  TCHP,  A0A024RBM9,  F5GWH6,  Q9BT92,  F5GWH6p ...

Linkouts:  STRING  Pharos  UniProt  OMIM