DISEASES

Disease-gene associations mined from literature

Literature associating PENK and bone cancer

PENK [ENSP00000324248]

Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family.

Synonyms:  PENK,  A0A024R7V4,  E5RFR1,  E5RIP6,  E5RJ72 ...

Linkouts:  STRING  Pharos  UniProt  OMIM