DISEASES

Disease-gene associations mined from literature

Literature associating ZBTB7A and delta beta-thalassemia

ZBTB7A [ENSP00000323670]

Factor that binds to inducer of short transcripts protein 1; Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity); BTB domain containing

Synonyms:  ZBTB7A,  ZBTB7Ap,  hZBTB7A,  O95365,  DKFZp547O146 ...

Linkouts:  STRING  Pharos  UniProt  OMIM