Literature associating CD6 and inflammatory bowel disease 18
CD6 [ENSP00000323280]
T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as calcium- dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS . ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089,
Synonyms: CD6, CD6p, hCD6, E7ER04, F5H835 ...