Literature associating LRSAM1 and acute kidney tubular necrosis
Leucine-rich repeat and sterile alpha motif-containing protein 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy); Ring finger proteins
Synonyms: LRSAM1, LRSAM1p, hLRSAM1, A0A024R870, Q6UWE0 ...