Literature associating POLE and nemaline myopathy 3
DNA polymerase epsilon catalytic subunit A; Catalytic component of the DNA polymerase epsilon complex . Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair . Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation .
Synonyms: POLE, A0A087WW42, A0A087WX51, F5H1D6, F5H7E4 ...