Disease-gene associations mined from literature

Literature associating RNF185 and uremic neuropathy

RNF185 [ENSP00000320508]

RING-type E3 ubiquitin transferase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2; Ring finger proteins

Synonyms:  RNF185,  RNF185p,  hRNF185,  A0A024R1F5,  A0A024R1H4 ...

Linkouts:  STRING  Pharos  UniProt