DISEASES

Disease-gene associations mined from literature

Literature associating EMR2 and vibratory urticaria

EMR2 [ENSP00000319883]

Egf-like module containing, mucin-like, hormone receptor-like 2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

Synonyms:  EMR2,  EMR2p,  hEMR2,  ADGRE2,  B4DQ88 ...

Linkouts:  STRING  Pharos  UniProt