DISEASES

Disease-gene associations mined from literature

Literature associating CXCR2 and lung disease

CXCR2 [ENSP00000319635]

High affinity interleukin-8 receptor B; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Synonyms:  CXCR2,  CXCR2p,  hCXCR2,  C9J1J7,  C9J2F9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM