Literature associating CXCR2 and lung disease
High affinity interleukin-8 receptor B; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Synonyms: CXCR2, CXCR2p, hCXCR2, C9J1J7, C9J2F9 ...