DISEASES

Disease-gene associations mined from literature

Literature associating SKA3 and uterine adnexa cancer

SKA3 [ENSP00000319417]

Spindle and kinetochore associated complex subunit 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.

Synonyms:  SKA3,  SKA3p,  hSKA3,  F5GWG1,  F5H8H7 ...

Linkouts:  STRING  Pharos  UniProt