Disease-gene associations mined from literature

Literature associating GEN1 and external ear disease

GEN1 [ENSP00000318977]

GEN1 Holliday junction 5' flap endonuclease; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.

Synonyms:  GEN1,  GEN1p,  hGEN1,  E9PLG0,  E9PM30 ...

Linkouts:  STRING  Pharos  UniProt  OMIM