Literature associating CYP8B1 and bile duct disease
7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids; Cytochrome P450 family 8
Synonyms: CYP8B1, CYP8B1p, hCYP8B1, C9JFR9, Q9UNU6 ...