Literature associating HSPH1 and cystic fibrosis
Heat shock 105kDa/110kDa protein 1; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity); Heat shock 70kDa proteins
Synonyms: HSPH1, HSPH1p, hHSPH1, A0A024RDQ0, A0A024RDS1 ...