Disease-gene associations mined from literature

Literature associating HSPH1 and cystic fibrosis

HSPH1 [ENSP00000318687]

Heat shock 105kDa/110kDa protein 1; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity); Heat shock 70kDa proteins

Synonyms:  HSPH1,  HSPH1p,  hHSPH1,  A0A024RDQ0,  A0A024RDS1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM