DISEASES

Disease-gene associations mined from literature

Literature associating GREM2 and tooth agenesis

GREM2 [ENSP00000318650]

Cysteine knot superfamily 1, BMP antagonist 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.

Synonyms:  GREM2,  GREM2p,  hGREM2,  A0A024R3Y1,  Q9H772 ...

Linkouts:  STRING  Pharos  UniProt  OMIM