DISEASES

Disease-gene associations mined from literature

Literature associating TLK2 and pica disease

TLK2 [ENSP00000316512]

Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Synonyms:  TLK2,  TLK2p,  hTLK2,  J3KRK0,  J3KST4 ...

Linkouts:  STRING  Pharos  UniProt