DISEASES

Disease-gene associations mined from literature

Literature associating HTR1A and bipolar I disorder

HTR1A [ENSP00000316244]

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Synonyms:  HTR1A,  HTR1Ap,  hHTR1A,  5HT1A,  D6RA34 ...

Linkouts:  STRING  Pharos  UniProt  OMIM