DISEASES

Disease-gene associations mined from literature

Literature associating DIS3L2 and nephroblastoma

DIS3L2 [ENSP00000315569]

DIS3 like 3'-5' exoribonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Synonyms:  DIS3L2,  DIS3L2p,  hDIS3L2,  C9JGP4,  H7C302 ...

Linkouts:  STRING  Pharos  UniProt  OMIM