Disease-gene associations mined from literature

Literature associating ADCK4 and focal segmental glomerulosclerosis 8

ADCK4 [ENSP00000315118]

AarF domain-containing protein kinase 4; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration.

Synonyms:  ADCK4,  ADCK4p,  hADCK4,  A0A024R0Q9,  COQ8B ...

Linkouts:  STRING  Pharos  UniProt  OMIM